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Original Research Article | OPEN ACCESS

Molecular Characterization of the Resistance of Mycobacterium tuberculosis to Second Line Drugs in Côte d’Ivoire

T Ouassa1 , YG Loukou1, A Dotia1, H Faye-Kette2

1Department of Bacteriology and Virology, Faculty of Pharmaceutical and Biological Sciences. University Félix Houphouët-Boigny, BP V34 Abidjan, Côte d’Ivoire; 2Department of Bacteriology and Virology, Faculty of Medical Sciences. University Félix Houphouët-Boigny, BP V34 Abidjan, Côte d’Ivoire.

For correspondence:-   Ouassa   Email: timouassa@yahoo.fr   Tel:+22502500078

Received: 14 June 2013        Accepted: 12 March 2014        Published: 23 May 2014

Citation: Ouassa T, Loukou Y, Dotia A, Faye-Kette H. Molecular Characterization of the Resistance of Mycobacterium tuberculosis to Second Line Drugs in Côte d’Ivoire. Trop J Pharm Res 2014; 13(5):727-730 doi: 10.4314/tjpr.v13i5.11

© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To characterize the resistance of Mycobacterium tuberculosis to second line drugs using a line probe assay.
Methods: Multi-drug resistant strains of Mycobacterium tuberculosis isolated between December 2008 and December 2009 were tested for resistance to fluoroquinolones and second-line injectable drugs using GenoType® MTBDRsl.
Results: Thirty eight strains gave interpretable results. None of them had a mutation in the gyrA gene. Regarding second-line injectable drugs, 4 strains (11 %) were resistant to aminoglycosides/ capreomycin and all of them harbored A1401G mutation.
Conclusion: No extensive drug resistant strains were observed. A relatively high proportion of strains were resistant to at least one second-line injectable drug. Resistance mechanism seemed similar for all of them.

Keywords: Mycobacterium tuberculosis, Line probe assay, GenoType® MTBDRsl, Aminoglycosides Capreomycin, Mutation

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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